About

My name is Jason H. Moore, Ph.D. and I am a retro computer and retro gaming enthusiast. As a kid in the 1970s and 1980s, I had an Atari 2600 Video Computer System (VCS) followed by an Atari 400 and then an Atari 800 home computer. I had exposure to other systems including the Apple II and Commodore VIC-20. I learned to program in BASIC and dabbled with Pilot and Assembly. I found the Atari systems to be very inspiring and my experience with them set up a lifelong interest in computer science and informatics that set the stage for my career as a biomedical informatician and AI researcher. This site is modeled after my successful Atari Projects site that now has over 300 project posts.

I am having tons of fun revisiting these old systems today. I have a pretty big collection of old systems including Atari, Apple, and Commodore. I have also tried my hand at developing a retro edutainment game called Gene Medic in assembly language for the Atari 2600. My goal with this web page is to share some of the fun I am having in the hopes that it will make it easy for others to carry out fun projects with their old systems. Enjoy!

Atari 400s
Atari 400s

If you are curious about my day job, I am Chair of the Department of Computational Biomedicine at Cedars-Sinai Medical Center where I direct the Center for Artificial Intelligence Research and Education and helped launch the new PhD Program in Health Artificial Intelligence. I do research on agentic artificial intelligence (AI) and automated machine learning (AutoML) algorithms and methods with application to biomedical and clinical data. Some of my recent AI projects include the tree-based pipeline optimization tool or TPOT, Aliro AI, AlzKB AI, KRAGEN, ESCARGOT, EcoXAI for Agentic AI. A central theme to my research is democratizing AI through automated machine learning and agentic AI. Here is my Health AI Insights Substack where I post about agentic AI for health care. I am @moorejh on Bluesky. Here is my LinkedIn page.

Here are a few of our research papers:

Agentic AI and the rise of in silico team science in biomedical research

The tree-based pipeline optimization tool: Tackling biomedical research problems with genetic programming and automated machine learning

Evaluation of a tree-based pipeline optimization tool for automating data science

TPOT: A tree-based pipeline optimization tool for automating machine learning

The tree-based pipeline optimization tool: Tackling biomedical research problems with genetic programming and automated machine learning

Scaling tree-based automated machine learning to biomedical big data with a feature set selector

Evaluating recommender systems for AI-driven biomedical informatics

The Alzheimer’s Knowledge Base: A knowledge graph for Alzheimer disease research

KRAGEN: a knowledge graph-enhanced RAG framework for biomedical problem solving using large language models

From prompt engineering to agent engineering: expanding the AI toolbox with autonomous agentic AI collaborators for biomedical discovery